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KMID : 0613820170270111376
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Journal of Life Science
2017 Volume.27 No. 11 p.1376 ~ p.1380
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The Effects of an Aqueous Extract from the Dried Roots of a Codonopsis pilosula (Franch.) Nannf. (CP) on the Body-weight Gains of Mice
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Lee Hyun-Tai
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Abstract
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This study examined how the daily administration of dried CP roots affects body-weight gains of mice. An aqueous CP extract (1 g/kg of CP-W) was orally administered to mice on a daily basis for ten weeks, and the mice's body weights and food intakes were measured throughout the period. At the end of the ten-week treatment, murine blood samples were taken and hematological and serum biochemical parameters were examined. The mice's intra-abdominal organs were weighed at necropsy. The treatment of CP-W significantly suppressed the mice's body-weight gain by about 10%. There were no changes to the food intakes of and no observable abnormal clinical signs in any of the animals throughout the experimental period. There were no significant differences between the control and CP-W mice in regards to the hematological and serum biochemical parameters and the organ weights at necropsy. The results demonstrated that the daily administration of CP-W for ten weeks suppresses body-weight gain in mice and does not change mice's food intake or cause any noticeable toxic effects.
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KEYWORD
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Body weight gain, Codonopsis pilosula, food intake, obesity, toxicity
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